Lexic.us

Definition of Immunoglobulin G

1. Noun. One of the five major classes of immunoglobulins; the main antibody defense against bacteria.

Medical Definition of Immunoglobulin G

1. The classical immunoglobulin class also called 7S IgG (150 kD). Composed of two identical light and two identical heavy chains, the constant region sequence of the heavy chains being of the type. The molecule can be described in another way as being composed of two Fab and an Fc fragment. The Fabs include the antigen combining sites, the Fc region consists of the remaining constant sequence domains of the heavy chains and contains cell binding and complement binding sites. Immunoglobulin Gs act on pathogens by agglutinating them, by opsonising them, by activating complement mediated reactions against cellular pathogens and by neutralising toxins. They can pass across the placenta to the foetus as maternal antibodies, unlike other Ig classes. In humans four main subclasses are known, IgG2 differs from the rest in not being transferred across the placenta and IgG4 does not fix complement. Immunoglobulin G is present at 8-16 mg/ml in serum. Synonym: gamma globulin. (30 Mar 1998)

Lexicographical Neighbors of Immunoglobulin G

Literary usage of Immunoglobulin G

Below you will find example usage of this term as found in modern and/or classical literature:

1. Science by American Association for the Advancement of Science (1883)
"... immunoglobulin G in nose drops, but not from those immunized parenterally. However, splenic lymphocytes from parenterally immunized animals inhibited ..."

2. Code of Federal Regulations, Title 21, Food and Drugs, Pt. 800-1299, Revised by Food and Drug Administration (FDA) Staff (2005)
"An immunoglobulin G (Fab ... of immunoglobulin G antibodies in unine, senum, and othen body fluids. ... of immunoglobulin G aids in the diagnosis of ..."

3. Manual of Microbiologic Monitoring of Laboratory Animals edited by Kim Waggie (1994)
"... virus: isolation of infectious virus-immunoglobulin G complexes and ... of specific antiviral immunoglobulin G response in wild-type and nude mice. ..."

4. Air Quality Criteria for Oxides of Nitrogenby Dennis J. Kotchmar by Dennis J. Kotchmar (1996)
"immunoglobulin G is the predominant class of immunoglobulins of the lower respiratory tract. These immunoglobulins act to enhance macrophage functioning. ..."

5. Reviews in Environmental Health (1998): Toxicological Defense Mechanics edited by Gary E. R. Hook, George W. Lucier (2000)
"... overlapping with childhood developmental windows and hapten-antigenic spreading; and model 1C is autoimmunity to immunoglobulin-G (IgG), ..."

6. Proceedings of the Society for Experimental Biology and Medicine (1903)
"... 241 use in analysis and isolation of a low molecular weight DNA fraction from rat hepatocytes, 158, 117 Chromium -labeled immunoglobulin G complexes, ..."

7. Chronic Fatigue Syndrome: Information for Physicians edited by Barry Leonard (1998)
"A controlled trial of intravenous immunoglobulin G in chronic fatigue syndrome. Am J Med. 1990;S9:554-560. 40. Lloyd A. Hickie I, Wakefield D, et al. ..."

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