Lexic.us

Definition of Glyoxalase

1. Noun. (biochemistry) Either of a pair of related thiol-dependent enzymes: ''glyoxalase ?'', which catalyses the isomerisation of the spontaneously formed hemithioacetal adduct between GSH and 2-oxoaldehydes (such as methylglyoxal) into S-2-hydroxyacylglutathione; and ''glyoxalase ??'', which hydrolyses these thiolesters. ¹

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