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Medical Definition of Closed reading frame
1. A sequence of DNA that cannot be translated into a viable protein; usually due to the interruption by one or more termination codons. Synonym: closed reading frame. (05 Mar 2000)
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1. A sequence of DNA that cannot be translated into a viable protein; usually due to the interruption by one or more termination codons. Synonym: closed reading frame. (05 Mar 2000)