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Medical Definition of Bartter's disease
1. Hypertrophy and hyperplasia of the juxtaglomerular cells, producing hypokalaemic alkalosis and hyperaldosteronism, characterised by absence of hypertension in the presence of markedly increased plasma renin concentrations, and by insensitivity to the pressor effects of angiotensin. It usually affects children, is perhaps hereditary, and may be associated with other anomalies, such as mental retardation and short stature. It is also called juxtaglomerular cell aplasia. (12 Dec 1998)