Definition of Down's syndrome

1. Noun. A congenital disorder caused by having an extra 21st chromosome; results in a flat face and short stature and mental retardation.


Medical Definition of Down's syndrome

1. A congenital disorder in which a person is born with three copies of chromosome 21 (trisomy 21). Clinical features include moderate to severe mental retardation, slanting eyes, a broad short skull, broad hands and short fingers. Other congenital abnormalities include heart defects, oesophageal atresia and an increased incidence of acute lymphocytic leukaemia. Trisomy 21 can be detected in the first few months of pregnancy by amniocentesis. Risk factors include prior child with Down's syndrome and mothers who become pregnant after age 40. This disorder was formerly known as mongolism. Incidence: 1 in 1000 births. (09 Oct 1997)

Lexicographical Neighbors of Down's Syndrome

dowitcher
dowitchers
dowl
Dowland
dowlas
dowlases
dowle
dowles
dowlne
dowlnes
dowlney
dowls
down
down
Down's syndrome
Down's syndrome
down(a)
down(p)
down-and-out
down-bow
down-regulation
down-to-earth
downa
downbeat
downbeats
downbeat nystagmus
downbound
downbow
downbows
downburst

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