Definition of Down-regulation

1. Noun. (alternative spelling of downregulation) ¹

¹ Source: wiktionary.com

Medical Definition of Down-regulation

1. Development of a refractory or tolerant state consequent upon repeated administration of a pharmacologically or physiologically active substance. It is the process that decreases ligand and receptor interactions or reduces the responsiveness of a cell to a stimulus following first exposure. This is often accompanied by an initial decrease in affinity of receptors for the agent and a subsequent reduction in the number of available receptors expressed on the surface which can result from internalisation of the ligand:receptor complex or from decreased expression of the receptor. Classically the concept referred to hormone receptors but contemporary usage includes other cell surface receptors. (03 Jul 1999)

Lexicographical Neighbors of Down-regulation

dowlney
dowls
down
down(a)
down(p)
down-
down-and-out
down-and-outer
down-and-outers
down-at-heel
down-bow
down-gyved
down-home
down-line
down-low
down-regulation (current term)
down-set
down-style
down-time
down-to-earth
down-town
down a shot
down and out
down antiquark
down antiquarks
down at heel
down at the heel
down at the heels
down bow
down bows

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