Definition of Insertional mutagenesis

1. Noun. (genetics) a mutation caused by the insertion of exogenous DNA into a genome.

Category relationships: Genetic Science, Genetics
Generic synonyms: Mutagenesis



Medical Definition of Insertional mutagenesis

1. Generally, mutagenesis of DNA by the insertion of one or more bases. Specific examples: 1. Oncogenesis by insertion of a retrovirus adjacent to a cellular proto-oncogene. 2. A strategy of mutagenesis with transposons. After a round of transposition, progeny are screened by PCR, with transposon and gene specific primers, for the proximity of the transposon sequence to the gene of interest. As PCR can only produce products up to 1-2 kb, a large fraction of progeny identified as positive by PCR will have a transposon close enough to the gene to inactivate or otherwise alter its pattern of expression. This entry appears with permission from the Dictionary of Cell and Molecular Biology (11 Mar 2008)

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Lexicographical Neighbors of Insertional Mutagenesis

insertable
inserted
inserter
inserters
insertest
inserteth
insertin
inserting
insertion
insertion mutation
insertion order
insertion orders
insertion sequence
insertional
insertional inactivation
insertional mutagenesis (current term)
insertions
insertosome
inserts
inserve
inserved
inserves
inservice training
inserving
insession
insessions
insessor
insessores
insessorial
insessors

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