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Definition of Trimethoprim-sulfamethoxazole
1. Noun. (pharmaceutical drug) A combination of trimethoprim and sulfamethoxazole in the ratio of 1 to 5. ¹
¹ Source: wiktionary.com
Medical Definition of Trimethoprim-sulfamethoxazole
1. A drug combination consisting of a dihydrofolate reductase inhibitor (trimethoprim) and a sulfonamide antibacterial drug (sulfamethoxazole). The drug combination is synergistic as the drugs interfere with two successive steps in the formation/utilization of folic acid by microorganisms. Used to treat many infectious diseases. (05 Mar 2000)