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Medical Definition of Mercapturic acid pathway
1. A glutathione-dependent pathway for the detoxification of a number of compounds, including arene oxides; an S-substituted glutathione is formed and ultimately converted to a mercapturic acid (an S-substituted N-acetylated l-cysteine), which is excreted; the leukotrienes are believed to be degraded through this pathway. (05 Mar 2000)