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Medical Definition of Major histocompatibility complex
1. The set of gene loci specifying major histocompatibility antigens, for example HLA in man, H 2 in mice, RLA in rabbits, RT 1 in rats, DLA in dogs, SLA in pigs, etc. Acronym: MHC This entry appears with permission from the Dictionary of Cell and Molecular Biology (11 Mar 2008)