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Medical Definition of Major depression
1. A clinical syndrome that includes a persistent sad mood or loss of interest in activities that persists for at least 2 weeks in the absence of external precipitants. This should not be confused with a grief reaction (death of loved one). Features may include change in eating habits, insomnia, early morning wakening, lack of interest, depressed mood, fatigue and suicidal thoughts. (27 Sep 1997)