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Medical Definition of Isovalerylcoenzyme A
1. The condensation product of isovaleric acid and coenzyme A; an intermediate in the catabolism of l-leucine. Synonym: isovalerylcoenzyme A. Isovaleryl-CoA dehydrogenase, an enzyme that participates in the catabolism of l-leucine; it converts isovaleryl-CoA to 3-methylcrotonyl-CoA using FAD; a deficiency in this enzyme will result in isovaleric acidemia. (05 Mar 2000)