Lexic.us

¹ Source: wiktionary.com

Definition of Immunodiffusion

1. [n -S]

Medical Definition of Immunodiffusion

1. The classical technique used to detect the presence of antibodies and determine their specificity by visualisation of precipitin lines. A technique for analysing antigen and antibody mixtures by watching them as they diffuse toward each other within a support medium (usually a gel). The precipitin lines (precipitated antigen-antibody complexes) form where the binding concentrations of antigen and antibody are equivalent. Patient serum diffuses from one well through the gel and reacts with a known specific antigen (or antibody) which diffuses through the gel from a second well. Immunodiffusion is strictly qualitative, although the density of the precipitin line and the distance of the line from the sample well may give some indication of the antibody concentration. Synonym: double diffusion, Ouchterlony technique. (01 Dec 1998)

Lexicographical Neighbors of Immunodiffusion

Literary usage of Immunodiffusion

Below you will find example usage of this term as found in modern and/or classical literature:

1. Science by American Association for the Advancement of Science (1883)
"The same antibody (undiluted) was used in the immunodiffusion method, and a known antigen-positive serum was used in wells spaced appropriately to confirm ..."

2. Proceedings of the Society for Experimental Biology and Medicine (1903)
"Immunologic analysis of type !P in the urine showed that it differed doubly fractionated type 8 PCP vaccine. >uble immunodiffusion in agarose, ..."

3. Code of Federal Regulations, Title 21, Food and Drugs, Pt. 800-1299, Revised by Food and Drug Administration (FDA) Staff (2005)
"... Radial plate. immunodiffusion (a) Identification. ... immunodiffusion plate fon clinical use is a ..."

4. Diarrhea and Malnutrition: Interactions, Mechanisms, and Interventions by Lincoln C. Chen, Nevin S. Scrimshaw (1983)
"Once secreted into the gut, alpha 1-antitrypsin is resistant to further breakdown and its quantity can be measured by the radial immunodiffusion technique ..."

5. Manual of Microbiologic Monitoring of Laboratory Animals edited by Kim Waggie (1994)
"Agar gel immunodiffusion has been described as less sensitive than agglutination or IFA (20). ELISA is a more sensitive method and has been used ..."

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