Medical Definition of Guanylate cyclase
1.
That is responsible for catalysing the synthesis of guanosine 3', 5' cyclic monophosphate from guanosine 5' triphosphate (cyclic GMP cGMP) is used as a second messenger in heart muscle and photoreceptor cells). Plasma membrane form of guanylate cyclase is Integral membrane proteins with an extracellular receptor for peptide hormones, a transmembrane domain, a protein kinase like domain and a guanylate cyclase domain.
Examples: sea urchin receptors for speract and resact and atrial natriuretic peptide receptors. Two soluble forms of guanylate cyclase are also known they are heterodimers of highly related subunits, 70-80 kD.
This entry appears with permission from the Dictionary of Cell and Molecular Biology
(11 Mar 2008)
Lexicographical Neighbors of Guanylate Cyclase
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