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Medical Definition of Endothelin-1
1. A 21-amino acid peptide produced in a variety of tissues including endothelial and vascular smooth-muscle cells, neurons and astrocytes in the central nervous system, and endometrial cells. It acts as a modulator of vasomotor tone, cell proliferation, and hormone production. (n eng j med 1995;333(6):356-63) (12 Dec 1998)