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Medical Definition of Blood group substance
1. Blood group-specific substances A and B, solution of complexes of polysaccharides and amino acids that reduces the titre of anti-A and anti-B isoagglutinins in serum from group O persons; used to render group O blood reasonably safe for transfusion into persons of group A, B, or AB, but does not affect any incompatibility that results from various other factors, such as Rh. (05 Mar 2000)