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Medical Definition of Anti-DNAse B
1. This is a serologic blood test used to detect antibodies against antideoxyribonuclease B (anti-DNAse B), an antigen that is produced by group A streptococci. This test is used to document a previous streptococcal infection in those who are suspected of having post-streptococcal disease (for example acute glomerulonephritis, rheumatic fever). A normal value is a negative assay. In adults this is less than 85 Todd units /ml. In school-age children this is less than 170 Todd units/ml. In pre-schoolers this is less than 60 Todd units/ml. Anywhere from 70 to 80% of people with rheumatic fever or post-streptococcal acute glomerulonephritis will have elevated anti-DNAse B levels. The test is performed on a venipuncture specimen. (27 Sep 1997)