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Medical Definition of Uhthoff's sign
1. A transient temperature-dependent numbness, weakness, or loss of vision. Conduction stops in any nerve if the temperature gets too high. In a damaged nerve, e.g., by demyelinization, this shutdown temperature is lowered, and may approach normal body temperature. Transient neurological dysfunction may then appear with a hot shower, exercise, or fever. Synonym: Uhthoff syndrome. (05 Mar 2000)
Lexicographical Neighbors of Uhthoff's Sign
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