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Definition of Sweet Sixteen
1. Proper noun. (basketball US informal) The sixteen teams participating in the regional semifinals of the NCAA Division I tournament, one of whom will become the national champion. ¹
2. Proper noun. (basketball US informal) The round of the NCAA Division I basketball tournament where all but 16 teams have been eliminated. ¹
3. Proper noun. (basketball US informal) An appearance in the Sweet Sixteen. ¹
4. Proper noun. A party for one's sixteenth birthday. ¹
5. Noun. (US colloquial) A girl's sixteenth birthday, or sixteenth-birthday party and a related coming of age party ¹
¹ Source: wiktionary.com