Medical Definition of Michaelis-menten constant

1. The true dissociation constant for the enzyme-substrate binary complex in a single-substrate rapid equilibrium enzyme-catalyzed reaction (usually symbolised by Ks), the concentration of the substrate at which half the true maximum velocity of an enzyme-catalyzed reaction is achieved (when velocities are measured under initial rate and steady state conditions). The ratio of rate constants (k2 + k3)/k1 in the single-substrate enzyme-catalyzed reaction: E + S &dblarr; ES &dblarr; E + products where E represents the free enzyme, S is the substrate, and ES is the central binary complex. The expression for the Michaelis constant will be more complex for multisubstrate reactions. An apparent Michaelis constant is a constant determined either under conditions that are not strictly steady state and initial rate or one that varies with the concentration of one or more cosubstrates. See: Michaelis-Menten equation. Synonym: Michaelis-Menten constant. (05 Mar 2000)

Lexicographical Neighbors of Michaelis-Menten Constant

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mice minute virus
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Michael
Michaelis-Gutmann body
Michaelis-Menten constant
Michaelis-Menten equation
Michaelis-Menten hypothesis
Michaelis complex
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Michael Assat
Michael Ellis De Bakey
Michael Faraday
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