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Medical Definition of Maxam Gilbert method
1. A method of DNA sequencing, based on the controlled degradation of a DNA fragment in a set of independent, nucleotide specific reactions. The resulting fragments have characteristic sizes depending on the sequence of the template, that can be resolved on a sequencing gel. Although no longer the main protocol, Maxam Gilbert sequencing still has advantages, for example for oligonucleotides or covalently modified DNA. See: dideoxy sequencing. This entry appears with permission from the Dictionary of Cell and Molecular Biology (11 Mar 2008)
Lexicographical Neighbors of Maxam Gilbert Method
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