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Definition of Isthmus of panama
1. Noun. The isthmus that connects Central America and South America; was formerly called the Isthmus of Darien. "Balboa crossed the Isthmus of Darien"
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1. Noun. The isthmus that connects Central America and South America; was formerly called the Isthmus of Darien. "Balboa crossed the Isthmus of Darien"