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Medical Definition of Dukes' classification
1. A classification of the extent of operable adenocarcinoma of the colon or rectum commonly modified as follows: A (Duke's A), confined to the mucosa; B1, into the muscularis mucosae; B2, through the muscularis mucosae; C1, limited to the bowel wall, with nodal metastases; C2, through the bowel wall, with nodal metastases. (05 Mar 2000)