Medical Definition of Factor IIa

1. Protease (34 kD) generated in blood clotting that acts on fibrinogen to produce fibrin. Consists of two chains, A and B, linked by a disulphide bond. B chain has sequence homology with pancreatic serine proteases: cleaves at Arg Gly. Thrombin is produced from prothrombin by the action either of the extrinsic system (tissue factor + phospholipid) or, more importantly, the intrinsic system (contact of blood with a foreign surface or connective tissue). Both extrinsic and intrinsic systems activate plasma factor X to form factor Xa which then, in conjunction with phospholipid (tissue derived or platelet factor 3) and factor V, catalyses the conversion. This entry appears with permission from the Dictionary of Cell and Molecular Biology (11 Mar 2008)



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Lexicographical Neighbors of Factor IIa

factoidal
factoids
factor
factor 3
factor A
factor B
factor D
factor E
factor Gm
factor H
factor III
factor IIa (current term)
factor IV
factor Inv
factor P
factor V1a
factor X for Haemophilus
factor analyse
factor analysis
factor analytic
factor analytical
factor analyze
factor in
factor ix
factor ix deficiency

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