Lexic.us

Definition of Tumour necrosis factor

1. Noun. A proinflammatory cytokine that is produced by white blood cells (monocytes and macrophages); has an antineoplastic effect but causes inflammation (as in rheumatoid arthritis).

Medical Definition of Tumour necrosis factor

1. Originally described as a tumour inhibiting factor in the blood of animals exposed to bacterial lipopolysaccharide or Bacille Calmette-Guerin. Preferentially kills tumour cells in vivo and in vitro, causes necrosis of certain transplanted tumours in mice and inhibits experimental metastases. Human Tumour Necrosis factor alpha is a protein of 157 amino acids and has a wide range of pro inflammatory actions. Usually considered a cytokine. Synonym: cachectin. Acronym: TNF (13 Nov 1997)

Lexicographical Neighbors of Tumour Necrosis Factor

Literary usage of Tumour necrosis factor

Below you will find example usage of this term as found in modern and/or classical literature:

1. Reviews in Environmental Health (1998): Toxicological Defense Mechanics edited by Gary E. R. Hook, George W. Lucier (2000)
"... patients: role of tumour necrosis factor-alpha (TNF-alpha). Clin Exp Immunol 106:541-548 (1996). Cell Physiol 135:23 (1988). 49. Piguet PF, Collari MA, ..."

2. Oxygen/Nitrogen Radicals and Cellular Injury edited by Kenneth B. Adler, Robert D. Devlin, Val Vallyathan (2000)
"... Takeyama N, Tanaka T. DNA damage induced by tumour necrosis factor-alpha in L929 cells 49. is mediated by mitochondrial oxygen radical formation. ..."

3. Novel Systems for the Study of Human Disease: From Basic Research to by OECD Staff, (Paris) Organisation for Economic Co-ope (1998)
"... in the downregulation of T cell receptor activation (Marengere et al., 1996). tumour necrosis factor Receptor p55 tumour necrosis factors TNFa and ..."

4. Discover Your Creator Contacting You by Alan Fraser Bell, Heather Louise Bell (2002)
"... tumour necrosis factor 100 TV - Audience Feel God's Presence 146 TV - Telepathy Alan with Brian Inglis 170 Twitch 125, 133, 150, 152, 154 Two or more ..."

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