Medical Definition of Transducin
1.
A GTP-binding protein found in the disc membrane of retinal rods and cones: of the part of the cascade involved in transduction of light to a nervous impulse.
A complex of three subunits, alpha (39 kD), beta (36 kD) and gamma (8 kD). Photoexcited rhodopsin interacts with transducin and promotes the exchange of GTP for GDP on the _ subunit.
The GTP _ subunit dissociates from the complex and activates a cGMP phospodiesterase by removing an inhibitory subunit. The _ subunit of transducin can be ADP ribosylated by cholera toxin and pertussis toxin.
This entry appears with permission from the Dictionary of Cell and Molecular Biology
(11 Mar 2008)
Lexicographical Neighbors of Transducin
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