Lexic.us

Definition of Thiouracil

1. Noun. Depresses the function of the thyroid gland.

Definition of Thiouracil

1. Noun. (organic compound) Any of a class of heterocycles based on ''2-thioxo-1H-pyrimidin-4-one''; the parent compound interferes with the synthesis of thyroxine and is used in the treatment of hyperthyroidism ¹

¹ Source: wiktionary.com

Definition of Thiouracil

1. [n -S]

Medical Definition of Thiouracil

1. Occurs in seeds of brassica and crucifera species. Thiouracil has been used as antithyroid, coronary vasodilator, and in congestive heart failure although its use has been largely supplanted by other drugs. It is known to cause blood dyscrasias and suspected of terato- and carcinogenesis. Pharmacological action: antimetabolites, antithyroid agents, vasodilator agents. Chemical name: 4(1H)-Pyrimidinone, 2,3-dihydro-2-thioxo- (12 Dec 1998)

Lexicographical Neighbors of Thiouracil

Literary usage of Thiouracil

Below you will find example usage of this term as found in modern and/or classical literature:

1. The Journal of Comparative Pathology and Therapeutics (1888)
"thiouracil 0-5 mg., subcutaneously, daily for 10 days before and up to 6 days after virus. Cortisone 0-5 mg., subcutaneously, daily for 2 days before and 4 ..."

2. Review of American Chemical Research by Massachusetts Institute of Technology, Arthur Amos Noyes, William Albert Noyes (1905)
"... in concentrated aqueous solution, the solution cooled and precipitated with acetic acid. The thiouracil thus obtained crystallizes from alcohol or water ..."

3. Second Report of the Expert Panel on Detection, Evaluation, and Treatment of ...by Scott M. Grundy by Scott M. Grundy (1997)
"Atherosclerosis and arteriosclerosis in dogs following ingestion of cholesterol and thiouracil. Arch Pathol 1946;42:433-44. 47. ..."

4. Reviews in Environmental Health (1998): Toxicological Defense Mechanics edited by Gary E. R. Hook, George W. Lucier (2000)
"Fundam Appi Toxicol 27:287-290 (1995). 367. Davenport JW, Dorcey TP. Hypothyroidism: learning deficit induced in rats by early exposure to thiouracil. ..."

5. Mineral Tolerance of Animals by National Research Council (U. S.) (2005)
"thiouracil only inhibits Type I deiodinase (IDI). A major difference exists between ruminants and nonruminants with respect to ID 1 ; this enzyme is ..."

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