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Medical Definition of Thiol activated haemolysins
1. Cytolytic bacterial exotoxins that act by binding to cholesterol in cell membranes and forming ring like complexes that act as pores. SH groups of these toxins must be in the reduced state for the toxin to function. Oxidation (to disulphide bridges) inactivates the toxin. Examples: tetanolysin, streptolysin O, _ toxin, cereolysin. This entry appears with permission from the Dictionary of Cell and Molecular Biology (11 Mar 2008)