Lexic.us

Definition of Thioguanine

1. Noun. An antineoplastic drug used to treat acute leukemias.

Definition of Thioguanine

1. Noun. (organic compound) A derivative of guanine obtained by replacing the carbonyl group with a thiol; it is an antineoplastic agent ¹

¹ Source: wiktionary.com

Medical Definition of Thioguanine

1. 2-amino-1,7-dihydro-6h-purine-6-thione. An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukaemia. Pharmacological action: antimetabolites, antineoplastic. Chemical name: 6H-Purine-6-thione, 2-amino-1,7-dihydro- (12 Dec 1998)

Lexicographical Neighbors of Thioguanine

Literary usage of Thioguanine

Below you will find example usage of this term as found in modern and/or classical literature:

1. A Lifelong Passion: Nicholas and Alexandra: Their Own Story by Andrei Maylunas (2005)
"The frequency of 6-thioguanine-resistant peripheral blood lymphocytes has been determined by autoradiography in a control population and a population of ..."

2. Biologic Markers in Pulmonary Toxicology by National Research Council (U.S.). Subcommittee on Pulmonary Toxicology (1989)
"Cells that are deficient in HPRT can proliferate in the presence of the toxic purine analogue 6-thioguanine, whereas HPRT-normal cells cannot. ..."

3. Novel Systems for the Study of Human Disease: From Basic Research to by OECD Staff, (Paris) Organisation for Economic Co-ope (1998)
"... then to select for cells resistant to both G418, a neomycin analogue, and 6-thioguanine (6-TG), a drug toxic to cells with a functional hprt gene. ..."

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