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Medical Definition of Sister chromatid exchange
1. An aberrant crossing-over event in which there is an exchange of segments between the sister chromatids of a chromosome, either between the sister chromatids of a meiotic tetrad or between the sister chromatids of a duplicated somatic chromosome. It can be induced by ultraviolet and ionizing radiation or by mutagenic agents and is observed by autoradiography. (12 Dec 1998)