Lexic.us

Definition of Simvastatin

1. Noun. An oral lipid-lowering medicine (trade name Zocor) administered to reduce blood cholesterol levels; recommended after heart attacks.

Definition of Simvastatin

1. Noun. A hypolipidemic drug used to control hypercholesterolemia and to prevent cardiovascular disease. ¹

¹ Source: wiktionary.com

Medical Definition of Simvastatin

1. A derivative of lovastatin and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme a reductase (hydroxymethylglutaryl CoA reductases), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic ldl receptors, it increases breakdown of ldl-cholesterol (lipoproteins, ldl cholesterol). Pharmacological action: anticholesteraemic agents, antilipaemic agents, hydroxymethylglutaryl-CoA reductase inhibitors. (12 Dec 1998)

Lexicographical Neighbors of Simvastatin

Literary usage of Simvastatin

Below you will find example usage of this term as found in modern and/or classical literature:

1. Second Report of the Expert Panel on Detection, Evaluation, and Treatment of ...by Scott M. Grundy by Scott M. Grundy (1997)
">9 The FDA recommends that lovastatin be taken with the evening meal, pravastatin at bedtime, and simvastatin in the evening. Reductions in LDL- cholesterol ..."

2. Building a Better Delivery System: A New Engineering/Health Care Partnership by Proctor P. Reid, National Academy of Engineering, Institute of Medicine (U.S.) (2005)
"High-dose atorvastatin vs usual-dose simvastatin for secondary prevention after myocardial infarction: the IDEAL study: A randomized controlled trial. ..."

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