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Definition of Serum disease
1. Noun. A delayed allergic reaction to the injection of an antiserum caused by an antibody reaction to an antigen in the donor serum.
Medical Definition of Serum disease
1. A hypersensitivity response (type III) to the injection of large amounts of antigen, as might happen when large amounts of antiserum are given in a passive immunisation. The effects are caused by the presence of soluble immune complexes in the tissues. This entry appears with permission from the Dictionary of Cell and Molecular Biology (11 Mar 2008)