Definition of Secretase
1. Noun. A set of enzymes believed to snip pieces off a longer protein producing fragments of amyloid protein that bunch up and create amyloid protein plaques in brain tissue (the pathological hallmark of Alzheimer's).
Medical Definition of Secretase
1.
Hypothetical proteinase which cleaves amyloid beta-precursor protein in betaa4 domain (residue 16) to generate the secreted form of app; comes in three putative forms (alpha, beta, gamma); beta and gamma forms form beta-protein from precursor, while alpha form cleaves precursor in middle so no beta-protein forms
Registry number: EC 3.4.99.-
Synonym: app secretase, amyloid precursor protein secretase, alpha-secretase, beta-secretase, gamma-secretase
(26 Jun 1999)
Lexicographical Neighbors of Secretase
Other Resources:
