Lexic.us

Definition of Secretase

1. Noun. A set of enzymes believed to snip pieces off a longer protein producing fragments of amyloid protein that bunch up and create amyloid protein plaques in brain tissue (the pathological hallmark of Alzheimer's).

Definition of Secretase

1. Noun. (biochemistry) An enzyme that "snips" pieces off a longer protein that is embedded in the cell membrane. ¹

¹ Source: wiktionary.com

Medical Definition of Secretase

1. Hypothetical proteinase which cleaves amyloid beta-precursor protein in betaa4 domain (residue 16) to generate the secreted form of app; comes in three putative forms (alpha, beta, gamma); beta and gamma forms form beta-protein from precursor, while alpha form cleaves precursor in middle so no beta-protein forms Registry number: EC 3.4.99.- Synonym: app secretase, amyloid precursor protein secretase, alpha-secretase, beta-secretase, gamma-secretase (26 Jun 1999)

Lexicographical Neighbors of Secretase

Literary usage of Secretase

Below you will find example usage of this term as found in modern and/or classical literature:

1. Novel Systems for the Study of Human Disease: From Basic Research to by OECD Staff, (Paris) Organisation for Economic Co-ope (1998)
"Normal processing by cx-secretase allows secretion of the ectodomain of APP ... To generate the B-amyloid peptide from APP the a-secretase cleavage must be ..."

2. Colección de documentos inéditos para la historia de España by Real Academia de la Historia (Spain) (1875)
"... quería que no fuese la fatiga suya y la gloria de otro, pues ambas cosas las habia beneficiado él; haciendo, pues, diligencias secretase! ..."

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