|
Definition of Sarcoglycan
1. Noun. Any of a family of transmembrane proteins involved in the protein complex responsible for connecting the muscle fibre cytoskeleton to the extracellular matrix, preventing damage to the muscle fibre sarcolemma through shearing forces. ¹
¹ Source: wiktionary.com
Medical Definition of Sarcoglycan
1. Complex of \0x85 and sarcoglycans. \0x85 sarcoglycan (50DAG, A2, adhalin), sarcoglycan (43DAG, A3b) and sarcoglycan (35DAG, A4) are all transmembrane glycoproteins that associate with dystroglycan in the sarcolemma approximate molecular weights are indicated by the old names). Defects in sarcoglycans have been shown to be associated with autosomally inherited muscular dystrophy. This entry appears with permission from the Dictionary of Cell and Molecular Biology (11 Mar 2008)