Lexic.us

Definition of Retinoblastoma

1. Noun. Malignant ocular tumor of retinal cells; usually occurs before the third year of life; composed of primitive small round retinal cells.

Definition of Retinoblastoma

1. Noun. (pathology) A malignant tumour of the retina; a hereditary condition found mostly in children. ¹

¹ Source: wiktionary.com

Definition of Retinoblastoma

1. [n -MAS or -MATA]

Medical Definition of Retinoblastoma

1. Malignant tumour of the retina, usually arising in the inner nuclear layer of the neural retina. Retinoblastoma is unusual in being caused by an autosomal dominant mutation in some cases (about 6%), in which case it may be bilateral. The gene product of the retinoblastoma gene is a tumour suppressor that interacts with transcription factors such as E2F to block transcription of growth regulating genes. The Rb gene plays a role in normal development, not just that of the retina. Inheritance: autosomal dominant. (03 Jul 1999)

Lexicographical Neighbors of Retinoblastoma

Literary usage of Retinoblastoma

Below you will find example usage of this term as found in modern and/or classical literature:

1. Novel Systems for the Study of Human Disease: From Basic Research to by OECD Staff, (Paris) Organisation for Economic Co-ope (1998)
"Rb mutation and retinoblastoma For most TSGs that have been targeted by our group, ... Specifically, in human familial retinoblastoma, inheritance of an RB ..."

2. Reviews in Environmental Health (1998): Toxicological Defense Mechanics edited by Gary E. R. Hook, George W. Lucier (2000)
"... we also demonstrated that the DNA binding of many common transcription factors (including Spl, retinoblastoma control proteins (RCPs), p53, ..."

3. Assessing the Human Health Risks of Trichloroethylene: Key Scientific Issues by National Research Council (U.S.) (2006)
"A cdk4/cdk6 system-mediated phosphorylation of retinoblastoma protein was down-regulated due to overexpression of pi6 (Korrapati etal. 2005). ..."

4. Review Of Fluoride: Benefits And Risks. Report Of The Ad Hoc Subcommittee On ...by DIANE Publishing Company by DIANE Publishing Company (1992)
"Osteosarcoma occurs excessively as a second primary cancer in children who have survived retinoblastoma and whose only treatment was surgery. ..."

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