Definition of Retinoblastoma
1. Noun. Malignant ocular tumor of retinal cells; usually occurs before the third year of life; composed of primitive small round retinal cells.
Definition of Retinoblastoma
1. Noun. (pathology) A malignant tumour of the retina; a hereditary condition found mostly in children. ¹
¹ Source: wiktionary.com
Definition of Retinoblastoma
1. [n -MAS or -MATA]
Medical Definition of Retinoblastoma
1.
Malignant tumour of the retina, usually arising in the inner nuclear layer of the neural retina.
Retinoblastoma is unusual in being caused by an autosomal dominant mutation in some cases (about 6%), in which case it may be bilateral.
The gene product of the retinoblastoma gene is a tumour suppressor that interacts with transcription factors such as E2F to block transcription of growth regulating genes. The Rb gene plays a role in normal development, not just that of the retina.
Inheritance: autosomal dominant.
(03 Jul 1999)
Lexicographical Neighbors of Retinoblastoma
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