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Medical Definition of Replication origin
1. A unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally. It contains the sites where the first separation of the complementary strands occurs, a primer RNA is synthesised, and the switch from primer RNA to DNA synthesis takes place. (rieger et al., glossary of genetics: classical and molecular, 5th ed) (12 Dec 1998)