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Medical Definition of Petrosal sinus sampling
1. Sampling of blood levels of the adrenocorticotropic hormone (acth) by withdrawal of blood from the inferior petrosal sinus. The inferior petrosal sinus arises from the cavernous sinus and runs to the internal jugular vein. Sampling of blood at this level is a valuable tool in the differential diagnosis of cushing disease, cushing syndrome, and other adrenocortical diseases. (12 Dec 1998)