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Medical Definition of Peptide elongation factor tu
1. A protein found in bacteria and eukaryotic cells which delivers aminoacyl-tRNA's to the a site of the ribosome. The aminoacyl-tRNA is first bound to a complex of elongation factor tu containing a molecule of bound GTP. The resulting complex is then bound to the 70s initiation complex. Simultaneously the GTP is hydrolyzed and a tu-GDP complex is released from the 70s ribosome. The tu-GTP complex is regenerated from the tu-GDP complex by the ts elongation factor and GTP. (12 Dec 1998)