Medical Definition of Paraneoplastic syndrome
1.
A collection of symptoms or clinical signs that are found in patients that have malignant disease. By definition, the signs and symptoms are not produced by a direct effect of a tumour or its metastasis nor due to direct invasion, compression, metastasis, infection, nutritional deficiency or treatment of the underlying neoplasm.
Paraneoplastic syndromes can arise from tumour produced biologically active polypeptides or proteins, autoimmunity or immune complex production and immune suppression, blockade of the normal effect of a hormone, the release of substances from tumour associated endothelium which are not normally released and finally unknown causes.
The best characterised paraneoplastic syndrome is the syndrome of inappropriate ADH.
(15 Dec 1997)
Lexicographical Neighbors of Paraneoplastic Syndrome
Other Resources:
