|
|
Medical Definition of Oncogene protein gp140(v-fms)
1. Transforming glycoprotein coded by the fms oncogene from the susan mcdonough strain of feline sarcoma virus (sm-fesv). The oncogene protein v-fms lacks sequences, which, in the highly homologous proto-oncogene protein c-fms (csf-1 receptor), normally serve to regulate its tyrosine kinase activity. The missing sequences in v-fms mimic the effect of ligand and lead to constitutive cell growth. The protein gp120(v-fms) is post-translationally modified to generate gp140(v-fms). (12 Dec 1998)
Lexicographical Neighbors of Oncogene Protein Gp140(v-fms)
Other Resources:
