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Medical Definition of Oligonucleotide probes
1. Synthetic or natural oligonucleotides used in hybridization studies in order to identify and study specific nucleic acid fragments, e.g., DNA segments near or within a specific gene locus or gene. The probe hybridises with a specific mRNA, if present. Conventional techniques used for testing for the hybridization product include dot blot assays, southern blot assays, and DNA:RNA hybrid-specific antibody tests. Conventional labels for the probe include the radioisotope labels 32p and 125i and the chemical label biotin. (12 Dec 1998)
Lexicographical Neighbors of Oligonucleotide Probes
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