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Medical Definition of Neuroglian
1. Protein isolated from Drosophila nervous system that is a member of the immunoglobulin superfamily. It contains 6 immunoglobulin like domains and 5 fibronectin type III domains and has strong sequence homology to mouse NCAM L1. Two different forms of neuroglian arise by differential splicing. These have identical extracellular domains but differ in the size of the cytoplasmic domains: the long form is restricted to neurons in CNS and PNS of embryos and larvae. This entry appears with permission from the Dictionary of Cell and Molecular Biology (11 Mar 2008)