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Medical Definition of Methionine synthase
1. Tetrahydropteroylglutamate methyltransferase; methionine-homocysteine methyltransferase;an enzyme that catalyses the reaction of N5-methyltetrahydrofolate with l-homocysteine to form tetrahydrofolate and l-methionine; a cobalamin-requiring enzyme; a deficiency of this enzyme results in an accumulation of l-homocysteine and neurological abnormalities. Synonym: tetrahydrofolate methyltransferase. (05 Mar 2000)