Lexic.us

Definition of Melphalan

1. Noun. Antineoplastic drug (trade name Alkeran) used to treat multiple myeloma and some other malignancies.

Definition of Melphalan

1. Noun. A particular drug used in chemotherapy. ¹

¹ Source: wiktionary.com

Definition of Melphalan

1. [n -S]

Medical Definition of Melphalan

1. An alkylating nitrogen mustard that is used as an antineoplastic in the form of the levo isomer - melphalan, the racaemic mixture - merphalan, and the dextro isomer - medphalan; toxic to bone marrow, but little vesicant action; potential carcinogen. Pharmacological action: antineoplastic agent, alkylating, carcinogens. Chemical name: L-Phenylalanine, 4-(bis(2-chloroethyl)amino)- (12 Dec 1998)

Lexicographical Neighbors of Melphalan

Literary usage of Melphalan

Below you will find example usage of this term as found in modern and/or classical literature:

1. 6th Annual Report on Carcinogens (1991) by DIANE Publishing Company (1994)
"Epi- demiological studies showed substantially increased rates of leukemia in patients treated with melphalan for breast cancer, ovarian cancer, ..."

2. Eighth Annual Report on Carcinogens: 1998 Summary edited by Barry Leonard (1999)
"melphalan CAS No. 148-82-3 First Listed in the First Annual Report on Carcinogens Carcinogenicity There is sufficient evidence for the carcinogenicity of ..."

3. Reviews in Environmental Health (1998): Toxicological Defense Mechanics edited by Gary E. R. Hook, George W. Lucier (2000)
"Intraperitoneal injection of 0.3 or 1.5 mg/kg melphalan, a chemotherapeutic ... Lung adenomas were also developed in melphalan-treated Tg and non-Tg mice. ..."

4. Carcinogenic Potency Database, Endocrine Disruptors edited by Lois Swirsky Gold (2000)
"Among the 5 human carcinogens, only aflatoxin and melphalan were evaluated as carcinogenic ... Three of these drugs were carcinogenic to monkeys (melphalan, ..."

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