Lexic.us

¹ Source: wiktionary.com

Definition of Mecamylamine

1. [n -S]

Medical Definition of Mecamylamine

1. A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool. Pharmacological action: antihypertensive agents, ganglionic blockers, nicotinic antagonists. Chemical name: Bicyclo(2.2.1)heptan-2-amine, N,2,3,3-tetramethyl- (12 Dec 1998)

Lexicographical Neighbors of Mecamylamine

Literary usage of Mecamylamine

Below you will find example usage of this term as found in modern and/or classical literature:

1. A Lifelong Passion: Nicholas and Alexandra: Their Own Story by Andrei Maylunas (2005)
"Pretreatment with mecamylamine (2 mg kg-1, sc) was effective in attenuating the stimulatory effect of either nicotine or cytisine. This study suggests that ..."

2. Health Consequences of Smoking: Nicotine Addiction a Report of the Surgeon by DIANE Publishing Company, C. Everett Koop, M.D. (1995)
"1982), (2) mecamylamine pretreatment diminishes the reinforcing efficacy of intravenous nicotine administration in animals (Goldberg et al. ..."

3. Problems of Drug Dependence: Proceedings of the 58th Annual Scientific Meeting by Louie S. Harrie (1999)
"The effects of mecamylamine on subjective responses to IV nicotine were evaluated in seven healthy male volunteer cigarette smokers who provided informed ..."

4. Nicotine in Cigarettes and Smokeless Tobacco Products Is a Drug and These edited by Barry Leonard (1999)
"One hour prior to each session, the subjects were given varying doses of oral A- mecamylamine. The presence of mecamylamine changed smoking behavior. ..."

5. Smokeless Tobacco Or Health: An International Perspective by DIANE Publishing Company (1993)
"In one study, acute administration of mecamylamine, a centrally active ... In this short- term experiment, mecamylamine actually increased indices of smoke ..."

6. Drug Abuse and Drug Abuse Research (1991): The Third Triennial Report to edited by MaryLouise Embrey, Christine R. Hartel (1999)
"Rose and co-workers (1989) showed that pretreating smokers with mecamylamine not only shifted their preference to higher dose levels of nicotine, ..."

7. Strategies to Control Tobacco Use in the U. S.: A Blueprint for Public (1991)
"mecamylamine has been suggested as an antagonist to block the nicotine-mediated reinforcing consequences of cigarette smoking (Henningfield et al., 1982; ..."

8. The Ftc Cigarette Test Method for Determining Tar, Nicotine & Carbon edited by Donald R. Shopland (1997)
"Nemeth-Coslett, R., Henningfield, JE, O'Keefe, MK, Griffiths, RR Effects of mecamylamine on human cigarette smoking and subjective ratings. ..."

Other Resources: