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Medical Definition of Lipogranulomatosis
1. 1. Presence of lipogranulomas. 2. Local inflammatory reaction to necrosis of adipose tissue. Disseminated lipogranulomatosis, a form of mucolipodosis, developing soon after birth because of deficiency of ceramidase; characterised by swollen joints, subcutaneous nodules, lymphadenopathy, and accumulation in lysosomes of affected cells of PAS-positive lipid consisting of ceramide. Synonym: Farber's disease, Farber's syndrome. (05 Mar 2000)