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Medical Definition of Lesser cul-de-sac
1. The initial portion of the pyloric part of the stomach, which may temporarily become partially or completely shut off from the remainder of the stomach during digestion by peristaltic contraction of the prepyloric "sphincter"; it is demarcated, sometimes, from the second part of the pyloric part of the stomach (pyloric canal) by a slight groove. Synonym: antrum pyloricum, antrum, lesser cul-de-sac. (05 Mar 2000)