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Medical Definition of Karnofsky performance status
1. A performance measure for rating the ability of a person to perform usual activities, evaluating a patient's progress after a therapeutic procedure, and determining a patient's suitability for therapy. It is used most commonly in the prognosis of cancer therapy, usually after chemotherapy and customarily administered before and after therapy. It was named for dr. David a. Karnofsky, an american specialist in cancer chemotherapy. (12 Dec 1998)