Medical Definition of Isocitrate dehydrogenase
1.
An enzyme of the oxidoreductase class that catalyses the conversion of isocitrate and NAD+ to yield 2-ketoglutarate, carbon dioxide, and NADH. It occurs in cell mitochondria. The enzyme requires magnesium, mn2+; it is activated by ADP, citrate, and calcium, and inhibited by NADH, NADPH, and ATP. The reaction is the key rate-limiting step of the citric acid (tricarboxylic) cycle. (the NADP+ enzyme is EC 1.1.1.42.)
Chemical name: Isocitrate:NAD+ oxidoreductase (decarboxylating)
Registry number: EC 1.1.1.41
(12 Dec 1998)
Lexicographical Neighbors of Isocitrate Dehydrogenase
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