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Definition of Intrinsic factor
1. Noun. A substance produced by the mucosa of the stomach and intestines that is essential for the absorption of vitamin B12. "Lack of intrinsic factor can result in pernicious anemia"
Generic synonyms: Factor
Medical Definition of Intrinsic factor
1. A mucoprotein normally secreted by the epithelium of the stomach and that binds vitamin B12, the intrinsic factor/B12 complex is selectively absorbed by the distal ileum, though only the vitamin is taken into the cell. This entry appears with permission from the Dictionary of Cell and Molecular Biology (11 Mar 2008)